Australian scientists identify biomarkers that cause sudden infant death
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Loading... - Mason Bell
- 25 May 2022
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In a breakthrough, Australian researchers have identified a biomarker that can detect babies more at risk of Sudden Infant Death Syndrome (SIDS) while they are alive.
SIDS is the unexplained death of an apparently healthy infant less than one year of age, during a period of sleep.
The incidence of SIDS has been more than halved in recent years due to public health campaigns addressing the known major risk factors of prone sleeping, maternal smoking and overheating. However, the rate of SIDS remains high, contributing to almost 50 per cent of all post-neonatal deaths in Western countries.
A team at the Children's Hospital at Westmead (CHW) identified Butyrylcholinesterase (BChE) as the biochemical marker that can help prevent death in infants.
In the study, published in The Lancets eBioMedicine, the team analysed BChE activity in 722 Dried Blood Spots (DBS) taken at birth as part of the Newborn Screening Programme.
BChE was measured in both SIDS and infants dying from other causes and each compared to 10 surviving infants with the same date of birth and gender.
The findings showed BChE levels were significantly lower in babies who subsequently died of SIDS compared to living controls and other infant deaths, said lead author Dr Carmel Harrington, research student at CHW, who lost her own child to SIDS 29 years ago.
BChE plays a major role in the brain's arousal pathway and researchers believe its deficiency likely indicates an arousal deficit, which reduces an infant's ability to wake or respond to the external environment, causing vulnerability to SIDS. Read More…
