Genetic Liability for ADHD, Schizophrenia, Increase Risk for Pregnancy-Related Factors
-
Loading... - michael mia
- 16 Aug 2022
- 75 Views
- 0 Like
- 0 Comment
Genetic liability for neurodevelopmental conditions increased the risk for many pregnancy-related factors, according to study results published in JAMA Psychiatry.
Investigators from the Norwegian Institute of Public Health sourced data from the Norwegian Mother, Father and Child Cohort Study (MoBa) which was a population-based pregnancy cohort study conducted between 1999 and 2008. Mothers (n=14,539) and fathers (n=14,897) gave blood samples to evaluate polygenetic scores (PGS) for attention-deficit/hyperactivity disorder (ADHD), autism, and schizophrenia. Genetic liabilities for neurodevelopmental conditions were related with pregnancy-related measures.
Maternal PGS for ADHD was significantly associated with 17 behavior and lifestyle characteristics, metabolic features, infectious and autoimmune diseases, indications for medicine use, and other physical health conditions related with pregnancy. The most significant associations were cigarette smoking (odds ratio [OR], 1.26; P =2.2´10–14), prepregnancy BMI (OR, 0.25; P =7.88´10–13), lifetime depression (OR, 1.12; P =3.73´10–9), maternal age (OR, -0.21; P =6.18´10–9), depression or anxiety symptoms (OR, 1.15; P =5.48´10–7), not taking supplements (OR, 1.09; P =7.04´10–5), weight gain (OR, 0.20; P =9.63´10–5), folate supplementation during pregnancy (OR, 0.92; P =3.23´10–4), and asthma (OR, 1.15; P =8.59´10–4).
For autism maternal PGS, there were seven significant associations, with lifetime depression (OR, 1.12; P =9.70´10–9) and depression or anxiety symptoms (OR, 1.13; P =3.62´10–5) as the most significant.
Schizophrenia PGS in mothers was associated with 11 pregnancy-related factors, particularly lifetime depression (OR, 1.16; P =3.11´10–13), prepregnancy BMI (OR, -0.18; P =2.26´10–7), coffee consumption (OR, 1.09; P =8.92´10–7), depression or anxiety symptoms (OR, 1.13; P =1.71´10–5), depression or anxiety medication use (OR, 1.37; P =3.72´10–5), depression medication use (OR, 1.43; P =2.76´10–5), and cigarette smoking (OR, 1.12; P =1.10´10–4). Read More…
