Ghana confirms first cases of deadly Marburg virus
It says both patients died recently in hospital in the southern Ashanti region.
Their samples came back positive earlier this month and have now been verified by a laboratory in Senegal.
Health officials in the West African nation say 98 people are now under quarantine as suspected contact cases.
These include relatives, medics and mortuary workers who came into contact with the two patients.
This is the second time that Marburg has been identified in West Africa. There was one confirmed case in Guinea last year, but that outbreak was declared over in September, five weeks after the case was discovered.
The World Health Organization (WHO), which is supporting Ghana's health authorities, has praised the country's swift response.
"This is good because without immediate and decisive action, Marburg can easily get out of hand," said Dr Matshidiso Moeti, the WHO's Africa director.
"There's a whole multi-disciplinary team in the field trying to ensure that we are able to unearth the real source of this," Dr Patrick Kumah-Aboagye, the head of Ghana's health service told BBC Focus on Africa radio.
Contact tracing and strict infection control measures have been introduced to prevent more fatalities.
Teams are also going into communities to make them aware of the symptoms and to ensure they alert health authorities if any suspected cases emerge.
No treatment yet exists for Marburg - but doctors say drinking plenty of water and treating specific symptoms improves a patient's chances of survival.
The virus is transmitted to people from fruit bats and spreads between humans through the transmission of bodily fluids. Read More…