Hungary PM in new anti-EU tirade amid protests by teachers
Speaking in the western city of Zalaegerszeg, Orban accused Brussels of "shooting" at Hungary with the sanctions.
"Let us not worry about those who are shooting at Hungary hidden in the shadows, somewhere from the watchtowers of Brussels," he said.
"They will end up where their predecessors ended up," he added, hinting that the EU could disintegrate as the Soviet bloc had.
Since the start of the conflict in Ukraine, Hungary - which is heavily dependent on imports of Russian energy - has nurtured its relations with the Kremlin so as to keep receiving gas and oil.
At the same time, Budapest has repeatedly denounced the EU sanctions as a disastrous to its economy.
Orban was speaking on the anniversary of the start of the 1956 Hungarian uprising against Soviet rule, which was eventually crushed when Moscow sent in tanks to crush the rebellion.
Last week, Budapest launched a "national consultation" survey of citizens about the EU's sanctions. Posters put up across the country declare: "The sanctions from Brussels are ruining us."

Although Hungary voted with his fellow EU member states for the sanctions, Orban has regularly protested the damage they have done to the country's economy. Read More...
"War on our doorstep, financial crisis and economic slowdown in the European Union, migratory invasion in the south, (...) we have to face multiple problems," said Orban on Sunday
But he insisted that his "strong and united" government would overcome such challenges. Read More...