Scientists discover a new drug-resistance mechanism in breast cancer
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Loading... - Oscar Hayes
- 07 Oct 2022
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Scientists from Università Cattolica in Rome, together with colleagues from the IIGM Foundation (part of Candiolo Institute at Turin), have discovered a new drug-resistance mechanism in breast cancer that leads to the formation of cancer stem cells, (the cells that feed the tumor and cause relapse and metastasis). They have also devised an experimental therapy to bypass or prevent the emergence of drug-resistance.
The results are published in Nature Immunology. The research was coordinated by Antonella Sistigu and Martina Musella, Department of Translational Medicine and Surgery, section of General Pathology and Clinical Pathology directed by Professor Ruggero De Maria and Ilio Vitale of the IIGM Foundation - Italian Institute for Genomic Medicine (part of the Compagnia di San Paolo Foundation), at Candiolo Institute, FPO-IRCCS, Candiolo (Turin). The project was funded by the AIRC Foundation and the Italian Ministry of Health."
Italian scientists discovered how the tumor evolves during treatment and develops resistance to therapies. "More specifically," Sistigu and Musella explain, "we have demonstrated that some tumor cells, while dying as result of chemotherapy, release in the tumor microenvironment a group of factors called "alarmins," which, normally alert and activate the immune system. However, paradoxically, some of these alarmins, such as type I interferons, can reprogram residual cancer cells and transform them into cancer stem cells, the deadly reservoir of the tumor. These stem cells are responsible, for example, for disease recurrence and metastasis.
Cancer stem cells escape the control of the immune system and have high invasive and aggressive potential. Read More...
